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Mitochondria, which retain ancestral bacterial motifs, are released into the cytosol or extracellular space as DAMPs upon cellular damage and are sensed by innate immune receptors to initiate inflammatory and antimicrobial defense responses

Pharmacol Res 187:106563 Liu Y, Wan Y, Jiang Y, Zhang L, Cheng W (2023b) GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Yap-1 promotes tregs differentiation in hepatocellular carcinoma by enhancing tgfbr2 transcription

Hence, the presence of l-alanine in the l-alanyl-l-glutamine dipeptide or in its free form and supplemented in tandem, can spare glutamine metabolism in order for the latter to be used by high-demand tissues under inflammatory and/or highly catabolic situations (Reference Cruzat, Pantaleao and Donato7,Reference Cruzat and Tirapegui32)